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Health Facts PlusDrug Information: Histrelin (Systemic)
is a type of medicine called a gonadotropin-releasing hormone (GnRH) antagonist that lowers the male hormone testosterone in your blood. Testosterone makes most prostate cancers grow. The histrelin implant is a drug-delivery system that contains the medicine histrelin and is placed under the skin. After it is placed under the skin it releases histrelin to the body continuously for 12 months. Histrelin is not a cure for prostate cancer but it may help to relieve the symptoms of prostate cancer.This medicine is available only with your doctor''s prescription, in the following dosage forms:Parenteral
Before Using This MedicineReturn to top
In deciding to use a medicine, the risks of using the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For histrelin, the following should be considered:
Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to GnRH, GnRH agonist analogs or to histrelin or any of its ingredients. Also tell your doctor and pharmacist if you are allergic to any other substances, such as foods, preservatives, or dyes.
Pregnancy—Histrelin is not for use in women.
Children—Histrelin is not for use in children.
Older adults—This medicine has been tested and has not been shown to cause different side effects or other problems in older people than it does in younger adults.
Other medicines—Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your health care professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.Other medical problems—The presence of other medical problems may affect the use of histrelin. Make sure you tell your doctor if you have any other medical problems, especially:Nerve problems caused by bone lesions in spine or
Problems in passing urine—Conditions may get worse for a short time after histrelin treatment is started
Proper Use of This MedicineReturn to top
Histrelin comes with patient instructions. Read these instructions carefully .Do not remove the pressure bandage or wet the inserted arm for 24 hours after insertion of the implant.Refrain from heavy lifting and strenuous physical activity of the inserted arm for 7 days to allow the incision to fully close.Do not remove the surgical strips, rather allow them to fall off on there own after several days.Dosing—Histrelin is placed under the skin of the inside of your upper arm. After it is placed under the skin it will give your body histrelin for 12 months.For 12-month implant dosage form : For prostate cancerAdults—one implant every 12 months.
Missed dose—If you are using this medicine every 12 months and you miss a dose, receive it as soon as possible, and go back to your regular dosing schedule.Storage—To store this medicine:Keep out of the reach of children.
Store away from heat and direct light.
Precautions While Using This MedicineReturn to top
It is very important that your doctor check your progress at regular visits to ensure histrelin implant is in place and functioning in your body.This medicine may cause loss in bone mineral density with extended treatment. Loss in bone mineral density can lead to the thinning of bones (osteoporosis). If you have any questions about this ask your doctor. Side Effects of This MedicineReturn to top
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
decreased frequency or amount of urine;
swelling of face, fingers, lower legs;
Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome.
local infection, irritation, redness or swelling to skin ;
redness of the face, neck, arms and occasionally, upper chest;
difficulty having a bowel movement (stool);
inability to have or keep an erection;
loss in sexual ability, desire, drive, or performance;
swelling of the breasts or breast soreness in both females and males;
fast, irregular, pounding, or racing heartbeat or pulse;
general feeling of discomfort or illness;
increased hair growth on forehead, back, arms, and legs;
itching or pain of the genital area;
large amount of cholesterol in the blood;
large, flat, blue or purplish patches in the skin;
shakiness in legs, arms, hands, feet;
trembling or shaking of hands or feet;
Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.
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